Transient hyperphosphatasemia in a child with nephrolithiasis and severe prematurity

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Transient hyperphosphatasemia in children.

Transient Hyperphosphatasemia (TH) is a benign condition in which serum alkaline phosphatase (ALP) is transiently elevated in the absence of other systemic diseases. It mainly occurs in infants and children and very rarely seen in adults. The differential diagnosis may include liver, bone, kidney, intestinal, placental and blood diseases as well as other serious conditions as well as bone fract...

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Transient hyperphosphatasemia in a child with autosomal recessive vitamin D dependency.

The case of a 4.5-year-old girl with autosomal recessive vitamin D dependency is described. Although she had been effectively treated since one month postpartum with 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3, alfacalcidol], her mean alkaline phosphatase (EC 3.1.3.1) activity in serum increased to 3680 U/L from a stable value [335 (SD 50) U/L; n = 12] within three weeks, then returned to bas...

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bENIgN trANSIENt hyPErPhoSPhAtASEmIA of ChIlDhooD

Objective: To report a case series of benign transient hyperphosphatasemia of infancy (BTHI). Description (Case report): A series of four girls with BTHI is described. The age range was 11-45 months (median: 13 months). At diagnosis, the serum alkaline phosphatase was 1.16.1 times (median: 1.36) above the reference values. Return to normal values occurred between 7-11 months (median: 9 months)....

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Normal Bone Turnover in Transient Hyperphosphatasemia

Transient hyperphosphatasemia of infancy and early childhood (THI) is characterized by a temporary isolated elevation of serum alkaline phosphatase activity (ALP), predominantly its bone or liver isoform, in either sick or healthy children under 5 years of age. Return to normal ALP levels usually occurs within four months. Spontaneous rise of ALP might concern the physician, especially when tre...

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A case of palmoplantar hyperkeratosis with periodontosis and a history of recurrent severe pyoderma, pneumonia and multiple liver abscesses is described in a 12 year old girl. The patient demonstrated neutrophil dysfunction characterized by decreased random migration and chemotaxis and defective bactericidal activity. The exact immunopathological mechanism for susceptibility to infections i...

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ژورنال

عنوان ژورنال: Nefrología (English Edition)

سال: 2017

ISSN: 2013-2514

DOI: 10.1016/j.nefroe.2017.06.007